We are all familiar, in some shape or form, with the idea of wanting to feel comfortable in our own skin. For most, these feelings are psychological, but imagine if your skin itself was uncomfortable to live in? For the 230 million people worldwide living with atopic dermatitis, this can be their reality.1
Atopic dermatitis, more commonly known as eczema, is a chronic, inflammatory skin disease.1,2 It is common, so we have all likely heard someone in our lives talking about eczema before, but we may not be aware of the realities of living with the oftentimes debilitating symptoms, such as chronic itch and painful lesions which can cause persistent discomfort in some patients’ day-to-day lives.1,2 If you recognize any of these symptoms in yourself, consider consulting your physician for guidance and support.
For many, the impact of atopic dermatitis also extends beyond the skin.3 Professor Silverberg, MD, PhD, MPH, Professor of Dermatology at the George Washington University School of Medicine and Health Sciences in Washington, DC, sees this firsthand in his patients, explaining that the condition “impacts their ability to sleep and really disrupts their daily life.”
Jiwon, who lives with atopic dermatitis and shared with us her personal experience, echoes this. She explains: “Itch impacts me and my ability to function. It affects all aspects of my life, from work to socializing with my friends.” In fact, over a third of adults with atopic dermatitis steer clear of social engagements due to the visible discomfort and appearance of their condition.4
Whilst many associate itch and skin lesions with surface level irritants, such as dry skin or exposure to allergens, atopic dermatitis is different – it’s a signal of deeper neuroimmune dysregulation.1,5,6
There are different treatment options for atopic dermatitis based on the severity of the condition, which should be discussed with a healthcare professional. Many patients manage their symptoms by choosing clothing carefully, adjusting their diets, or utilizing creams and ointments.1,4 And for some, topical treatments can provide meaningful relief.1,4 For others, these approaches may not be enough.7-9 “While the creams and the topicals are very effective in reducing inflammation, the itch itself seems to come from deep within,” shares Michelle, who also lives with atopic dermatitis, describing her personal story. For those with moderate to severe atopic dermatitis, advanced therapies – such as biologics – could be more appropriate.
Atopic dermatitis isn’t one-size-fits-all, and neither is its treatment. Recognizing the full spectrum of symptoms and tailoring care accordingly can help patients reclaim comfort, confidence, and control in their daily lives.
References
Langan SM, Irvine AD, Weidinger S. Atopic dermatitis [published correction appears in Lancet. 2020;396(10253):758]. Lancet. 2020;396(10247):345-360. doi: 10.1016/S0140- 6736(20)31286-1
Yang G, et al. Skin Barrier Abnormalities and Immune Dysfunction in Atopic Dermatitis. Int J Mol Sci. 2020;21(8):2867. doi: doi.org/10.3390/ijms21082867
Silverberg JI, et al. Patient burden and quality of life in atopic dermatitis in US adults: a population-based cross-sectional study. Ann Allergy Asthma Immunol. 2018;121(3):340-347. doi: 10.1016/j.anai.2018.07.006
Silverberg JI. Comorbidities and the impact of atopic dermatitis. Ann Allergy Asthma Immunol. 2019;123(2):144-151. doi: 10.1016/j.anai.2019.04.020
Bağci IS and Ruzicka T. IL-31: A new key player in dermatology and beyond. J Allergy Clin Immunol. 2018;141(3):P858-866. doi: 10.1016/j.jaci.2017.10.045
Datsi A, et al. Interleukin-31: The “itchy” cytokine in inflammation and therapy. Allergy. 2021;76:2982-2997. doi: 10.1111/all.14791
Lobefaro F, et al. Atopic Dermatitis: Clinical Aspects and Unmet Needs. Biomedicines.2022;10:2927.doi.org/10.3390/biomedicines10112927
Katoh N, Ohya Y, Ikeda M, et al. Clinical practice guidelines for the management of atopic dermatitis 2018. J Dermatol. 2019;46(12):1053-1101. doi: 10.1111/1346-8138.15090
Kwatra SG, Misery L, Clibborn C, Steinhoff M. Molecular and cellular mechanisms of itch and pain in atopic dermatitis and implications for novel therapeutics. Clin Transl Immunology. 2022;11(5):e1390. doi: 10.1002/cti2.1390